MICAL1 |
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Available structures |
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PDB | Ortholog search: |
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List of PDB id codes |
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1WYL, 2CO8 |
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Identifiers |
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Aliases | MICAL1, MICAL, MICAL-1, NICAL, microtubule associated monooxygenase, calponin and LIM domain containing 1 |
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External IDs | OMIM: 607129MGI: 2385847HomoloGene: 11246GeneCards: MICAL1 |
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Gene location (Human) |
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Chr. | Chromosome 6 (human)[1] |
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Band | 6q21 | Start | 109,444,062 bp[1] |
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End | 109,465,968 bp[1] |
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Gene location (Mouse) |
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Chr. | Chromosome 10 (mouse)[2] |
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Band | 10|10 B2 | Start | 41,476,314 bp[2] |
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End | 41,487,032 bp[2] |
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RNA expression pattern |
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More reference expression data |
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Gene ontology |
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Molecular function | •SH3 domain binding •oxidoreductase activity •actin binding •oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen •FAD binding •Rab GTPase binding •GO:0001948 protein binding •metal ion binding •protein kinase binding •monooxygenase activity •NAD(P)H oxidase activity •actin filament binding
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Cellular component | •cytoplasm •cytoskeleton •intermediate filament •hippocampal mossy fiber expansion •cytosol •midbody •intercellular bridge •cell membrane •actin cytoskeleton
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Biological process | •negative regulation of protein phosphorylation •actin filament depolymerization •sulfur oxidation •negative regulation of cysteine-type endopeptidase activity involved in apoptotic process •negative regulation of apoptotic process •oxidation-reduction process •cytoskeleton organization •signal transduction •regulation of regulated secretory pathway •blood coagulation
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Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) | NM_022765 NM_001159291 NM_001286613 |
| NM_001164433 NM_138315 NM_001358838 NM_001358839 |
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RefSeq (protein) | NP_001152763 NP_001273542 NP_073602 |
| NP_001157905 NP_612188 NP_001345767 NP_001345768 |
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Location (UCSC) | Chr 6: 109.44 – 109.47 Mb | Chr 10: 41.48 – 41.49 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Mical Campbell, M.D. Primary Location. New London Care Center 234 A Bank Street, 4th Floor New London, CT 06320 Phone: 860-442-0290 Fax: 860-442-2136. Undergraduate Education. Harvard University. JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. (PMID: 16525024) Terai T Sasaki T (Molecular biology of the cell 2006) 2 3 4; MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman JR Kolodkin AL (Cell 2002) 2 3 4. MICAL2 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2) is a Protein Coding gene. Diseases associated with MICAL2 include Fraser Syndrome 1.Gene Ontology (GO) annotations related to this gene include actin binding and flavin adenine dinucleotide binding.An important paralog of this gene is MICAL3. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. (PMID: 24440334) Lundquist MR Jaffrey SR (Cell 2014) 3 4; Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers. (PMID: 21596566) Grigoriev I Akhmanova A (Current biology: CB 2011) 3 4. Mical Raz, MD, PhD, MSHP holds the Charles E. Phelps Professorship in Public Policy and Health, and has been a hospitalist with URMC since 2019. She completed her medical training at Tel Aviv University, from where she also received a PhD in history of medicine.
NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1gene.[5][6]
Interactions[edit]
MICAL1 has been shown to interact with NEDD9[5] and RAB1A.[7]
References[edit]
Micalizzi
- ^ abcGRCh38: Ensembl release 89: ENSG00000135596 - Ensembl, May 2017
- ^ abcGRCm38: Ensembl release 89: ENSMUSG00000019823 - Ensembl, May 2017
- ^'Human PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^'Mouse PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ abSuzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana K, Morimoto C, Hirai H (Apr 2002). 'MICAL, a novel CasL interacting molecule, associates with vimentin'. J Biol Chem. 277 (17): 14933–41. doi:10.1074/jbc.M111842200. PMID11827972.
- ^'Entrez Gene: MICAL1 microtubule associated monoxygenase, calponin and LIM domain containing 1'.
- ^Weide, Thomas; Teuber Julia; Bayer Michael; Barnekow Angelika (Jun 2003). 'MICAL-1 isoforms, novel rab1 interacting proteins'. Biochem. Biophys. Res. Commun. United States. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. ISSN0006-291X. PMID12788069.
Further reading[edit]
Micalla Rettinger
- Iwata S, Ohashi Y, Kamiguchi K, Morimoto C (2000). 'Beta 1-integrin-mediated cell signaling in T lymphocytes'. J. Dermatol. Sci. 23 (2): 75–86. doi:10.1016/S0923-1811(99)00096-1. PMID10808124.
- Maruyama K, Sugano S (1994). 'Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides'. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). 'Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library'. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
- Hattori A, Okumura K, Nagase T, et al. (2001). 'Characterization of long cDNA clones from human adult spleen'. DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID11214971.
- Terman JR, Mao T, Pasterkamp RJ, et al. (2002). 'MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion'. Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID12110185.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). 'Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences'. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID12477932.
- Weide T, Teuber J, Bayer M, Barnekow A (2003). 'MICAL-1 isoforms, novel rab1 interacting proteins'. Biochem. Biophys. Res. Commun. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. PMID12788069.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). 'The DNA sequence and analysis of human chromosome 6'. Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). 'Complete sequencing and characterization of 21,243 full-length human cDNAs'. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). 'The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)'. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID15489334.
- Fischer J, Weide T, Barnekow A (2005). 'The MICAL proteins and rab1: a possible link to the cytoskeleton?'. Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID15694364.
- Bayer M, Fischer J, Kremerskothen J, et al. (2006). 'Identification and characterization of Iporin as a novel interaction partner for rab1'. BMC Cell Biol. 6 (1): 15. doi:10.1186/1471-2121-6-15. PMC1079803. PMID15796781.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). 'Global, in vivo, and site-specific phosphorylation dynamics in signaling networks'. Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983. S2CID7827573.
- Jin X, Zhang J, Dai H, et al. (2007). 'Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain'. Biophys. Chem. 129 (2–3): 269–78. doi:10.1016/j.bpc.2007.06.008. PMID17662518.
Micallef Perfume
Micalea Smeltzer
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