MiCal



MICAL1
Available structures
PDBOrtholog search:
List of PDB id codes

1WYL, 2CO8

Identifiers
AliasesMICAL1, MICAL, MICAL-1, NICAL, microtubule associated monooxygenase, calponin and LIM domain containing 1
External IDsOMIM: 607129MGI: 2385847HomoloGene: 11246GeneCards: MICAL1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q21Start109,444,062 bp[1]
End109,465,968 bp[1]
Gene location (Mouse)
Chr.Chromosome 10 (mouse)[2]
Band10|10 B2Start41,476,314 bp[2]
End41,487,032 bp[2]
RNA expression pattern
More reference expression data
Gene ontology
Molecular functionSH3 domain binding
oxidoreductase activity
actin binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
FAD binding
Rab GTPase binding
GO:0001948 protein binding
metal ion binding
protein kinase binding
monooxygenase activity
NAD(P)H oxidase activity
actin filament binding
Cellular componentcytoplasm
cytoskeleton
intermediate filament
hippocampal mossy fiber expansion
cytosol
midbody
intercellular bridge
cell membrane
actin cytoskeleton
Biological processnegative regulation of protein phosphorylation
actin filament depolymerization
sulfur oxidation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of apoptotic process
oxidation-reduction process
cytoskeleton organization
signal transduction
regulation of regulated secretory pathway
blood coagulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022765
NM_001159291
NM_001286613

NM_001164433
NM_138315
NM_001358838
NM_001358839

RefSeq (protein)

NP_001152763
NP_001273542
NP_073602

NP_001157905
NP_612188
NP_001345767
NP_001345768

Location (UCSC)Chr 6: 109.44 – 109.47 MbChr 10: 41.48 – 41.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mical Campbell, M.D. Primary Location. New London Care Center 234 A Bank Street, 4th Floor New London, CT 06320 Phone: 860-442-0290 Fax: 860-442-2136. Undergraduate Education. Harvard University. JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. (PMID: 16525024) Terai T Sasaki T (Molecular biology of the cell 2006) 2 3 4; MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman JR Kolodkin AL (Cell 2002) 2 3 4. MICAL2 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2) is a Protein Coding gene. Diseases associated with MICAL2 include Fraser Syndrome 1.Gene Ontology (GO) annotations related to this gene include actin binding and flavin adenine dinucleotide binding.An important paralog of this gene is MICAL3. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. (PMID: 24440334) Lundquist MR Jaffrey SR (Cell 2014) 3 4; Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers. (PMID: 21596566) Grigoriev I Akhmanova A (Current biology: CB 2011) 3 4. Mical Raz, MD, PhD, MSHP holds the Charles E. Phelps Professorship in Public Policy and Health, and has been a hospitalist with URMC since 2019. She completed her medical training at Tel Aviv University, from where she also received a PhD in history of medicine.

NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1gene.[5][6]

MiCal


Interactions[edit]

MiCal

MICAL1 has been shown to interact with NEDD9[5] and RAB1A.[7]

References[edit]

Micalizzi

  1. ^ abcGRCh38: Ensembl release 89: ENSG00000135596 - Ensembl, May 2017
  2. ^ abcGRCm38: Ensembl release 89: ENSMUSG00000019823 - Ensembl, May 2017
  3. ^'Human PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^'Mouse PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ abSuzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana K, Morimoto C, Hirai H (Apr 2002). 'MICAL, a novel CasL interacting molecule, associates with vimentin'. J Biol Chem. 277 (17): 14933–41. doi:10.1074/jbc.M111842200. PMID11827972.
  6. ^'Entrez Gene: MICAL1 microtubule associated monoxygenase, calponin and LIM domain containing 1'.
  7. ^Weide, Thomas; Teuber Julia; Bayer Michael; Barnekow Angelika (Jun 2003). 'MICAL-1 isoforms, novel rab1 interacting proteins'. Biochem. Biophys. Res. Commun. United States. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. ISSN0006-291X. PMID12788069.

Further reading[edit]

Micalla Rettinger

  • Iwata S, Ohashi Y, Kamiguchi K, Morimoto C (2000). 'Beta 1-integrin-mediated cell signaling in T lymphocytes'. J. Dermatol. Sci. 23 (2): 75–86. doi:10.1016/S0923-1811(99)00096-1. PMID10808124.
  • Maruyama K, Sugano S (1994). 'Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides'. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). 'Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library'. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
  • Hattori A, Okumura K, Nagase T, et al. (2001). 'Characterization of long cDNA clones from human adult spleen'. DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID11214971.
  • Terman JR, Mao T, Pasterkamp RJ, et al. (2002). 'MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion'. Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID12110185.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). 'Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences'. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID12477932.
  • Weide T, Teuber J, Bayer M, Barnekow A (2003). 'MICAL-1 isoforms, novel rab1 interacting proteins'. Biochem. Biophys. Res. Commun. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. PMID12788069.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). 'The DNA sequence and analysis of human chromosome 6'. Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). 'Complete sequencing and characterization of 21,243 full-length human cDNAs'. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). 'The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)'. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID15489334.
  • Fischer J, Weide T, Barnekow A (2005). 'The MICAL proteins and rab1: a possible link to the cytoskeleton?'. Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID15694364.
  • Bayer M, Fischer J, Kremerskothen J, et al. (2006). 'Identification and characterization of Iporin as a novel interaction partner for rab1'. BMC Cell Biol. 6 (1): 15. doi:10.1186/1471-2121-6-15. PMC1079803. PMID15796781.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). 'Global, in vivo, and site-specific phosphorylation dynamics in signaling networks'. Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983. S2CID7827573.
  • Jin X, Zhang J, Dai H, et al. (2007). 'Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain'. Biophys. Chem. 129 (2–3): 269–78. doi:10.1016/j.bpc.2007.06.008. PMID17662518.

Micallef Perfume

MiCal


Micalea Smeltzer

Retrieved from 'https://en.wikipedia.org/w/index.php?title=MICAL1&oldid=994304611'